Interactions of Penicillium Spinulosum with Hemo and Nonpsychoactive Hemp Compounds (2020)

Dr. Sandra Bonetti, Chemistry

In nature, fungi and plants have developed close ecological relationships due to their co-evolution on earth. The interactions between fungi and plants are diverse and may be beneficial or detrimental depending on environmental conditions and the organisms involved. Mycorrhizal fungi are symbiotically associated plant host root systems, which provide enhanced water […]

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Anti-Cancer Potential of Fermented Dietary Hempseed (CANNABIS SATIVA L.) Metabolites and the Role of CB Receptors in Human Colon Cancer Cell CACO2 Viability, Proliferation, and Energy Metabolism (2020)

Dr. Annette Gabaldón, Biology

The objective of this study is to determine whether metabolites generated through probiotic fermentation of dietary hempseed (Cannabis sativa L.) exert anti-cancer effects. Specifically, we will culture human colorectal carcinoma cells Caco-2 in growth media supplemented with hempseed fermentation supernatant and test for alterations in cell viability, proliferation, and energy metabolism.

Previously, […]

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Sexually Dimorphic Effects of Cannabinoids on Cognitive and Reflexive Learning and Memory-Dependent Neuronal Network Activity in Mouse Hippocampus and Amygdala (2020)

Dr. Jeff Smith, Biology

The broad objectives of this proposed research are to quantitatively identify the degree to which electrical activity in specific neuronal populations that support fear learning and memory in the mammalian brain is targeted in a sexually dimorphic way by the cannabinoids; Dexanabinol, a synthetic cannabinoid used in human clinical trials for […]

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Data Analytics in Cannabis Research (2020)

Dr. Kuang-Yuan Huang, CIS

There are two goals of the proposed research. First, we will continue our ICR-funded research on analyzing the big data collected from a large cannabis online support forum. Specifically, the goal is to analyze the social network data constructed from the social interaction history among cannabis quitters in the online support […]

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Cannabis Use Survey Instrument Development and Implementation (2020)

Dr. Karen Yescavage, Psychology

The objective of this project is to engage in survey instrument development, assessing its psychometric properties, in order to build an empirical cannabis knowledge base. Once survey is both reliable and valid, objective is to research the reasons why people use and how they use cannabis, both medicinally and recreationally. Specific […]

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Applications of Industrial Hemp (Multi-Year Project) (2020)

Dr. Brian Vanden Heuvel, Biology

This project enables an inter-departmental, multi-faculty collaborative workflow that builds on 18 months of previous achievements by the principal investigator and co-principal investigators and established infrastructure through previous ICR funding. We believe that it is time to extend our work to applied projects.

Specifically, this proposal asks: 1) Can industrial hemp be […]

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Rheological characteristics of hemp-based filament composites for 3D printing (Multi-Year Project) (2020)

Dr. Neb Jaksic, Engineering 

This research investigates flow characteristics of various hemp-based composites used in 3D printing. It is an expansion to the research already in progress. While the current research is based on the goal of optimizing the hemp-plastic ratio in filament composites, this proposed research emphasizes understanding of underlying principles and it should further help […]

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An ongoing investigation into the effects of medicinal cannabis on seizures in adults with medically refractory epilepsy (Multi-Year Project) (2020)

Dr. Barbara Brett-Green, Psychology

The primary objective for this project is to continue an ongoing study into the effects of medicinal cannabis on seizures in adults with medically refractory epilepsy. The Principal Investigator has established a partnership with Realm of Caring, a nonprofit organization, to provide support services for patients, and iC42, a bioanalytics company, to […]

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Identification And Characterization of Hemp Components That Control Abnormal Proliferation of Human Rheumatoid Arthritis Fibroblast-like Synoviocytes And Triple-negative Breast Cancer Cells (Partnership Project)  (2020)

Dr. Sang Hyuck Park, Dr.Kyungho Lee

Both Rheumatoid arthritis (RA) and triple-negative breast cancer (TNBC) are characterized by abnormal proliferation and an association with an affected immune response. Abnormal proliferation and inflammation disrupt endoplasmic reticulum (ER) homeostasis and induce the unfolded protein response (UPR). The UPR is associated with the pathogenesis of various human diseases […]

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Formation of Cannabinoids in Glandular Trichomes of Cannabis (Partnership Project) (2020)

Dr. Sang Hyuck Park, Dr. Eun Soo Kim

This study will provide a base for a future thrust relating to a selection of hemp varieties. According to the morphological aspect, three types of glandular trichomes in Cannabis sativa are recognized: bulbous, capitate-sessile, and capitate-stalked trichomes. Capitate-stalked trichomes have garnered research interest, whereas the other two types of trichomes have […]

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Capturing Archaeal Biochemistry to Build Bigger Botanical Biomass in Cannabis (Partnership Project) (2020)

Dr. Nate Bickford

Oxidative stress is a byproduct of harsh environmental conditions and can limit efficient growth throughout the three kingdoms of life. Ultra-reactive side-products of an oxygen-based metabolism can damage critical cellular components and force programmed cell death. In plants, the cell’s redox status is intimately tied to interpreting environmental cues. Our preliminary data […]

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An ongoing investigation into the effects of medicinal cannabis on seizures in adults with medically refractory epilepsy (2019)

Principal Investigator: Dr. Barbara Brett-Green, Psychology

The primary objective for this project is to continue an ongoing study into the effects of medicinal cannabis on seizures in adults with medically refractory epilepsy. The Principal Investigator has established a partnership with Realm of Caring, a nonprofit organization, to provide support services for patients, and iC42, a […]

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Effects of dietary hempseed (Cannabis sativa L.) on growth patterns, body composition, bone mineral density, and gut microbiota diversity in female C57BL/6J mice (2019)

Principal Investigator: Dr. Annette Gabaldon, Biology 

The objective of this study is to understand the effects of dietary hempseed (Cannabis sativa L.) ingestion on growth patterns, body composition, bone mineral density, and gut microbiota diversity in female C57BL/6J mice. Hempseed is a nutrient-dense food which contains high amounts of protein, carbohydrate, fiber, lipids, vitamins, minerals, and phytochemicals, […]

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Detecting cannabinoid-induced alterations to cellular metabolism using a Seahorse XF Bioanalyzer and monitoring its impact on viral replication (2019)

Principal Investigators: Dr. Annette Gabaldon, Biology, and Dr. Brian Vanden Heuvel, Biology

Cannabinoid receptors are ubiquitous and are found on cells all throughout the body. Endogenous, exogenous, or synthetic cannabinoids can bind to the receptors and trigger a cellular response. It has been shown that activation of the CB1 receptor in liver cells increases metabolic […]

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Rheological characteristics of hemp-based filament composites for 3D printing (2019)

Principal Investigator: Dr. Neb Jaksic, Engineering 

This research investigates flow characteristics of various hemp-based composites used in 3D printing. It is an expansion to the research already in progress. While the current research is based on the goal of optimizing the hemp-plastic ratio in filament composites, this proposed research emphasizes understanding of underlying principles and it […]

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Big data analytics in cannabis research (2019)

Principal Investigator: Dr. Yoanna Long, CIS, Hasan School of Business

The primary objective of this research is two-fold. First, as a continuation of the current ICR-funded research, we will establish a data center to host and analyze cannabis-related data. As a component of the data center, during the next stage we will introduce data analytics […]

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K12 cannabis research project (2019)

Principal Investigator: Tim Peters

This study builds upon the work of the 2017-2018 K12 Pilot Study. The proposed 2018-2019 project will continue the focus on K12 student cannabis use, programs to prevent cannabis use, and interventions to address student violations of cannabis laws. Data will be collected from schools to determine trends in cannabis use […]

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Modulation of NMDA-Receptor Dependent Neurological Function by Dexanabinol (2019)

Principal Investigator: Dr. Jeff Smith, Biologya

The broad objectives of this proposed research are to characterize the inhibition of GluN2B subunit-containing NMDA receptors in mouse brain by the cannabinoid Dexanabinol (HU-211) and to demonstrate its relevance for modulating NMDA receptor-dependent learning and memory in mice at both the electrophysiological and behavioral levels.

The specific aims are […]

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Applications of industrial hemp (2019)

Principal Investigator: Dr. Brian Vanden Heuvel, Biologya

This project enables an inter-departmental, multi-faculty collaborative workflow that builds on 18 months of previous achievements by the principal investigator and co-principal investigators and established infrastructure through previous ICR funding. We believe that it is time to extend our work to applied projects.

Specifically, this proposal asks: 1) Can […]

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