Short-term Effects of Cannabis use and Cannabinoids in Youth: A Sibling-Comparison Study (2021)

Jarrod Ellingson, PhD
Assistant Professor, Psychiatry-Substance Dependence, University of Colorado School of Medicine

In the last 10 years, cannabis has become more accessible and more potent in tetrahydrocannabinol [THC] content. Prior studies have linked earlier cannabis use and greater THC potency to adverse mental health outcomes. However, these studies generally suffer from two important limitations. First, cannabis use has primarily been assessed in a pre-legalization environment, when THC potencies were lower. Second, most studies of adolescent cannabis use have not considered familial confounds, such as genetic or environmental factors. This study will recruit sibling pairs to examine the mental health effects of cannabis while controlling for important familial factors. Specifically, we will test whether participants with heavier cannabis use have worse mental health functioning, on average, compared to their sibling. Within this study design, we will also examine the short-term effects of adolescent cannabis use, such as whether school week functioning is affected by weekend cannabis use. Short-term effects are important because they can help to identify mechanisms of long-term effects. Thus, this study will help to understand the mental effects of cannabis in adolescents, while controlling for family background factors.

More Continuing Research

Dissecting the Genetic Basis of Sex and Dioecy in Cannabis Sativa (2021)

Nolan Kane, PhD

Associate Professor, Ecology and Evolutionary Biology, University of Colorado Boulder

As hemp continues to become an ever more economically valuable/important crop, it becomes increasingly necessary to understand the mechanism of sex determination. Understanding these processes will help to develop new approaches, tools, and pipelines, which will propel Cannabis into the modern era as […]

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Investigating the Effect of Cannabidiol and Cannabidiol-trazodone Combination Treatment on Naturally Occurring Canine Cognitive Dysfunction Syndrome as a Surrogate for Alzheimer’s Disease (2021)

Stephanie McGrath, PhD
Associate Professor, Neurology, Colorado State University

The World Health Organization predicts that Alzheimer’s disease (AD) and other dementias will be the second leading cause of death in the United States within the next decade. Unfortunately, multimodal treatment efforts, with drugs, vaccines, and stem cell therapies, have yet to be successful. Neurodegenerative disorders are […]

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Quantification of Endo- and Phytocannabinoids with Comparison to Pain Medication Requirements and Surgical Outcomes for Patients Undergoing Abdominal Surgery for Cancer (2021)

Camille Stewart, MD
Assistant Professor of Surgery, Division of Surgical Oncology, University of Colorado Anschutz Medical Campus

The use of cannabis is expanding in the United States. There is, however, a critical lacking in our understanding of how cannabis and its associated chemical compounds, called cannabinoids, affect patients after surgery. Patients undergoing abdominal surgery have substantial […]

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Exploring Intoxication During Acute Alcohol and Cannabis Co-Administration: A Focus on Cannabinoid Content and Order Effects (2021)

Hollis Karoly, PhD
Assistant Professor, Department of Psychology, Colorado State University

Cannabis is the most commonly used drug among people who drink alcohol, yet evidence on the effects of using these substances together is quite limited. Two important factors that might impact the relationship between cannabis and alcohol use are the specific type of cannabis used […]

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Defining the Effects of CBD Consumption During Pregnancy on Fetal Neurodevelopment and Postnatal Anxiety (2021)

Emily Bates, PhD
Associate Professor, Pediatrics-Developmental Biology, University of Colorado Anschutz Medical Campus

Morning sickness during pregnancy can be debilitating for a significant portion of women. Because there are not good remedies easily available and marijuana can help with nausea, women are drawn to using it, or the non-psychoactive component cannabidiol (CBD), thinking it is safe […]

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