Microbiome-Mediated Effects of Cannabis and CBD on Neurotransmitter-Related Molecular Networks and Anxiety (2021)

Nichole Reisdorph, PhD
Professor Mass Spectrometry Facility Director, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus

Orally consumed Cannabis and extracted cannabidiol (CBD) products are becoming widely used supplements for a range of health disorders, including depression and anxiety. However, there is limited understanding regarding how Cannabis and CBD affect those living with these and other psychiatric conditions. Personal reports and some early research studies suggest that the effects of orally consumed tetrahydrocannabinol (THC), CBD, and Cannabis are largely dependent on the individual. We hypothesize that some of this variability in a person’s response is due to differences in an individual’s gut microbiome composition. Therefore, our research will help determine if an individual’s gut microbiome plays a role in how he/she/they metabolize CBD, THC, and other Cannabis molecules when orally ingested. In addition, our research will help understand the effects of CBD and Cannabis on anxiety and depression by measuring important neurotransmitters known to be related to anxiety/depression. These include dopamine, serotonin, kynurenine, epinephrine, and several endocannabinoids. Results can be used to develop similar studies that focus on other conditions such as post-traumatic stress disorder (PTSD) and to determine if ingestion of a pro- or pre-biotic can influence an individual’s response to CBD or Cannabis.

More Continuing Research

Dissecting the Genetic Basis of Sex and Dioecy in Cannabis Sativa (2021)

Nolan Kane, PhD

Associate Professor, Ecology and Evolutionary Biology, University of Colorado Boulder

As hemp continues to become an ever more economically valuable/important crop, it becomes increasingly necessary to understand the mechanism of sex determination. Understanding these processes will help to develop new approaches, tools, and pipelines, which will propel Cannabis into the modern era as […]

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Investigating the Effect of Cannabidiol and Cannabidiol-trazodone Combination Treatment on Naturally Occurring Canine Cognitive Dysfunction Syndrome as a Surrogate for Alzheimer’s Disease (2021)

Stephanie McGrath, PhD
Associate Professor, Neurology, Colorado State University

The World Health Organization predicts that Alzheimer’s disease (AD) and other dementias will be the second leading cause of death in the United States within the next decade. Unfortunately, multimodal treatment efforts, with drugs, vaccines, and stem cell therapies, have yet to be successful. Neurodegenerative disorders are […]

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Quantification of Endo- and Phytocannabinoids with Comparison to Pain Medication Requirements and Surgical Outcomes for Patients Undergoing Abdominal Surgery for Cancer (2021)

Camille Stewart, MD
Assistant Professor of Surgery, Division of Surgical Oncology, University of Colorado Anschutz Medical Campus

The use of cannabis is expanding in the United States. There is, however, a critical lacking in our understanding of how cannabis and its associated chemical compounds, called cannabinoids, affect patients after surgery. Patients undergoing abdominal surgery have substantial […]

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Exploring Intoxication During Acute Alcohol and Cannabis Co-Administration: A Focus on Cannabinoid Content and Order Effects (2021)

Hollis Karoly, PhD
Assistant Professor, Department of Psychology, Colorado State University

Cannabis is the most commonly used drug among people who drink alcohol, yet evidence on the effects of using these substances together is quite limited. Two important factors that might impact the relationship between cannabis and alcohol use are the specific type of cannabis used […]

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Defining the Effects of CBD Consumption During Pregnancy on Fetal Neurodevelopment and Postnatal Anxiety (2021)

Emily Bates, PhD
Associate Professor, Pediatrics-Developmental Biology, University of Colorado Anschutz Medical Campus

Morning sickness during pregnancy can be debilitating for a significant portion of women. Because there are not good remedies easily available and marijuana can help with nausea, women are drawn to using it, or the non-psychoactive component cannabidiol (CBD), thinking it is safe […]

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