Short-term Effects of Cannabis use and Cannabinoids in Youth: A Sibling-Comparison Study (2021)
Jarrod Ellingson, PhD
Assistant Professor, Psychiatry-Substance Dependence, University of Colorado School of Medicine
In the last 10 years, cannabis has become more accessible and more potent in tetrahydrocannabinol [THC] content. Prior studies have linked earlier cannabis use and greater THC potency to adverse mental health outcomes. However, these studies generally suffer from two important […]
Microbiome-Mediated Effects of Cannabis and CBD on Neurotransmitter-Related Molecular Networks and Anxiety (2021)
Nichole Reisdorph, PhD
Professor Mass Spectrometry Facility Director, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus
Orally consumed Cannabis and extracted cannabidiol (CBD) products are becoming widely used supplements for a range of health disorders, including depression and anxiety. However, there is limited understanding regarding how Cannabis and CBD affect those living […]
Understanding Genomic Constituents of Cannabis and Genetic Regulation Underlying Cannabinoid Production (2021)
Dr. Sang Hyuck Park, ICR
The objective of the ICR research projects is to provide in-depth scientific evidence for better understanding the biology, chemistry, and physiology of Cannabis sativa L. to improve its agronomic values, as well as to extend the scope of the use of phytocannabinoids as a potential therapeutical agent. In […]
Anti-Cancer Potential of Fermented Dietary Hempseed (CANNABIS SATIVA L.) Metabolites and the Role of CB Receptors in Human Colon Cancer Cell CACO2 Viability, Proliferation, and Energy Metabolism (2021)
Dr. Annette Gabaldón, Biology
The objective of this study is to determine whether metabolites generated through probiotic fermentation of dietary hempseed (Cannabis sativa L.) exert anti-cancer effects. Specifically, we will culture human colorectal carcinoma cells Caco-2 in growth media supplemented with hempseed fermentation supernatant and test for alterations in cell viability, proliferation, and […]
Effects of Dietary Hempseed (Cannabis sativa L.) on Growth Patterns, Body Composition, Bone Mineral Density, and Gut Microbiota Diversity in Memale C57BL/6J Mice (2021)
Principal Investigator: Dr. Annette Gabaldon, Biology
The objective of this study is to understand the effects of dietary hempseed (Cannabis sativa L.) ingestion on growth patterns, body composition, bone mineral density, and gut microbiota diversity in female C57BL/6J mice. Hempseed is a nutrient-dense food which contains high amounts of protein, carbohydrate, fiber, lipids, […]
Applications of Industrial Hemp (2021)
Dr. Brian Vanden Heuvel, Biology
This project enables an inter-departmental, multi-faculty collaborative workflow that builds on 18 months of previous achievements by the principal investigator and co-principal investigators and established infrastructure through previous ICR funding. We believe that it is time to extend our work to applied projects.
Specifically, this proposal asks 1) […]
An Ongoing Investigation Into the Effects of Medicinal Cannabis on Seizures in Adults with Medically Refractory Epilepsy (2021)
Dr. Barbara Brett-Green, Psychology
The primary objective for this project is to continue an ongoing study into the effects of medicinal cannabis on seizures in adults with medically refractory epilepsy. The Principal Investigator has established a partnership with Realm of Caring, a nonprofit organization, to provide support services for patients, and iC42, a […]
Formation of Cannabinoids in Glandular Trichomes of Cannabis (Partnership Project) (2021)
Dr. Sang Hyuck Park, Dr. Eun Soo Kim
This study will provide a base for a future thrust relating to a selection of hemp varieties. According to the morphological aspect, three types of glandular trichomes in Cannabis sativa are recognized: bulbous, capitate-sessile, and capitate-stalked trichomes. Capitate-stalked trichomes have garnered research interest, whereas the […]
Understanding Genomic Constituents of Cannabis and Genetic Regulation Underlying Cannabinoid Production (2020)
Dr. Sang Hyuck Park, ICR
The objective of the ICR research projects is to provide in-depth scientific evidence for better understanding the biology, chemistry, and physiology of Cannabis sativa L. to improve its agronomic values, as well as to extend the scope of the use of phytocannabinoids as a potential therapeutical agent. In order to […]
Interactions of Penicillium Spinulosum with Hemo and Nonpsychoactive Hemp Compounds (2020)
Dr. Sandra Bonetti, Chemistry
In nature, fungi and plants have developed close ecological relationships due to their co-evolution on earth. The interactions between fungi and plants are diverse and may be beneficial or detrimental depending on environmental conditions and the organisms involved. Mycorrhizal fungi are symbiotically associated plant host root systems, which provide […]