Sexually Dimorphic Effects of Cannabinoids on Cognitive and Reflexive Learning and Memory-Dependent Neuronal Network Activity in Mouse Hippocampus and Amygdala (2020)
Dr. Jeff Smith, Biology
The broad objectives of this proposed research are to quantitatively identify the degree to which electrical activity in specific neuronal populations that support fear learning and memory in the mammalian brain is targeted in a sexually dimorphic way by the cannabinoids; Dexanabinol, a synthetic cannabinoid used in human clinical trials for […]
Data Analytics in Cannabis Research (2020)
Dr. Kuang-Yuan Huang, CIS
There are two goals of the proposed research. First, we will continue our ICR-funded research on analyzing the big data collected from a large cannabis online support forum. Specifically, the goal is to analyze the social network data constructed from the social interaction history among cannabis quitters in the online support […]
Cannabis Use Survey Instrument Development and Implementation (2020)
Dr. Karen Yescavage, Psychology
The objective of this project is to engage in survey instrument development, assessing its psychometric properties, in order to build an empirical cannabis knowledge base. Once survey is both reliable and valid, objective is to research the reasons why people use and how they use cannabis, both medicinally and recreationally. Specific […]
Applications of Industrial Hemp (Multi-Year Project) (2020)
Dr. Brian Vanden Heuvel, Biology
This project enables an inter-departmental, multi-faculty collaborative workflow that builds on 18 months of previous achievements by the principal investigator and co-principal investigators and established infrastructure through previous ICR funding. We believe that it is time to extend our work to applied projects.
Specifically, this proposal asks: 1) Can industrial hemp be […]
Rheological characteristics of hemp-based filament composites for 3D printing (Multi-Year Project) (2020)
Dr. Neb Jaksic, Engineering
This research investigates flow characteristics of various hemp-based composites used in 3D printing. It is an expansion to the research already in progress. While the current research is based on the goal of optimizing the hemp-plastic ratio in filament composites, this proposed research emphasizes understanding of underlying principles and it should further help […]
An ongoing investigation into the effects of medicinal cannabis on seizures in adults with medically refractory epilepsy (Multi-Year Project) (2020)
Dr. Barbara Brett-Green, Psychology
The primary objective for this project is to continue an ongoing study into the effects of medicinal cannabis on seizures in adults with medically refractory epilepsy. The Principal Investigator has established a partnership with Realm of Caring, a nonprofit organization, to provide support services for patients, and iC42, a bioanalytics company, to […]
Identification And Characterization of Hemp Components That Control Abnormal Proliferation of Human Rheumatoid Arthritis Fibroblast-like Synoviocytes And Triple-negative Breast Cancer Cells (Partnership Project) (2020)
Dr. Sang Hyuck Park, Dr.Kyungho Lee
Both Rheumatoid arthritis (RA) and triple-negative breast cancer (TNBC) are characterized by abnormal proliferation and an association with an affected immune response. Abnormal proliferation and inflammation disrupt endoplasmic reticulum (ER) homeostasis and induce the unfolded protein response (UPR). The UPR is associated with the pathogenesis of various human diseases […]
Formation of Cannabinoids in Glandular Trichomes of Cannabis (Partnership Project) (2020)
Dr. Sang Hyuck Park, Dr. Eun Soo Kim
This study will provide a base for a future thrust relating to a selection of hemp varieties. According to the morphological aspect, three types of glandular trichomes in Cannabis sativa are recognized: bulbous, capitate-sessile, and capitate-stalked trichomes. Capitate-stalked trichomes have garnered research interest, whereas the other two types of trichomes have […]
How Does CBD Modulate Learning and Memory in Humans? (Partnership Project) (2020)
Dr. Moussa Diawara, Dr. Jeff Smith, Dr. Libby Stuty, Ms. Amy Uhernik
Cannabidiol (CBD) is a form of cannabinoid that lacks the psychoactive (hight) effect associated with Tetrahydrocannabinol (THC), the primary cannabinoid found in cannabis. Research findings point to CBD as a possible memory-enhancing agent that could be used to treat cognitive disorders of L&M […]
Capturing Archaeal Biochemistry to Build Bigger Botanical Biomass in Cannabis (Partnership Project) (2020)
Dr. Nate Bickford
Oxidative stress is a byproduct of harsh environmental conditions and can limit efficient growth throughout the three kingdoms of life. Ultra-reactive side-products of an oxygen-based metabolism can damage critical cellular components and force programmed cell death. In plants, the cell’s redox status is intimately tied to interpreting environmental cues. Our preliminary data […]