Isolation and Pharmacological Evaluation of Phytocannabinoids for Alzheimer’s Disease (2022)
Duncan Mackie, PhD,
Director of Pharmacology & Experimental Therapeutics, MedPharm Holdings
Cinnamon Bidwell, PhD,
Institute of Cognitive Science Faculty, Assistant Professor, University of Colorado Boulder
Alzheimer’s disease is a leading cause of dementia and death in Colorado, impacting tens of thousands of families and placing a growing burden on caregivers and the healthcare system. Current treatments offer […]
Preventative and treatment effects of broad-spectrum cannabidiol (CBD) in a rat model of comorbid autism and epilepsy: A mechanistic study (2022)
Christopher Lowry, PhD
Associate Professor, Integrative Physiology, University of Colorado Boulder
This research project used a rat model of Autism Spectrum Disorder (ASD) to examine whether cannabidiol (CBD), a non-psychoactive compound found in cannabis, might help reduce symptoms associated with ASD. Over the past 25 years, the prevalence of ASD has risen dramatically, now affecting about […]
Dissecting the Genetic Basis of Sex and Dioecy in Cannabis Sativa (2021)
Nolan Kane, PhD
Associate Professor, Ecology and Evolutionary Biology, University of Colorado Boulder
As hemp continues to become an ever more economically valuable/important crop, it becomes increasingly necessary to understand the mechanism of sex determination. Understanding these processes will help to develop new approaches, tools, and pipelines, which will propel Cannabis into the modern era as […]
Observational Study of the Effects of Acute Cannabis Use on Ocular Activity Relevant to Driving (2021)
Ashley Brooks-Russell, PhD, MPH
Associate Professor, Director (IVPC), Colorado School of Public Health, University of Colorado Anschutz Medical Campus
Police officers have long recognized that changes to the eyes, such as changes to the pupils or eye movements, can be a sign of recent drug use. Emerging research has found that changes to eye movement may […]
Investigating the Effect of Cannabidiol and Cannabidiol-trazodone Combination Treatment on Naturally Occurring Canine Cognitive Dysfunction Syndrome as a Surrogate for Alzheimer’s Disease (2021)
Stephanie McGrath, PhD
Associate Professor, Neurology, Colorado State University
The World Health Organization predicts that Alzheimer’s disease (AD) and other dementias will be the second leading cause of death in the United States within the next decade. Unfortunately, multimodal treatment efforts, with drugs, vaccines, and stem cell therapies, have yet to be successful. Neurodegenerative disorders are […]
Quantification of Endo- and Phytocannabinoids with Comparison to Pain Medication Requirements and Surgical Outcomes for Patients Undergoing Abdominal Surgery for Cancer (2021)
Camille Stewart, MD
Assistant Professor of Surgery, Division of Surgical Oncology, University of Colorado Anschutz Medical Campus
The use of cannabis is expanding in the United States. There is, however, a critical lacking in our understanding of how cannabis and its associated chemical compounds, called cannabinoids, affect patients after surgery. Patients undergoing abdominal surgery have substantial […]
Exploring Intoxication During Acute Alcohol and Cannabis Co-Administration: A Focus on Cannabinoid Content and Order Effects (2021)
Hollis Karoly, PhD
Assistant Professor, Department of Psychology, Colorado State University
Cannabis is the most commonly used drug among people who drink alcohol, yet evidence on the effects of using these substances together is quite limited. Two important factors that might impact the relationship between cannabis and alcohol use are the specific type of cannabis used […]
Defining the Effects of CBD Consumption During Pregnancy on Fetal Neurodevelopment and Postnatal Anxiety (2021)
Emily Bates, PhD
Associate Professor, Pediatrics-Developmental Biology, University of Colorado Anschutz Medical Campus
Morning sickness during pregnancy can be debilitating for a significant portion of women. Because there are not good remedies easily available and marijuana can help with nausea, women are drawn to using it, or the non-psychoactive component cannabidiol (CBD), thinking it is safe […]
Is What You See What You Get? A Systematic, Public Health-driven Analysis of Cannabis Product Label Claims VS. Actual Cannabinoid Content (2021)
Cinnamon Bidwell, PhD
Institute of Cognitive Science Faculty, Assistant Professor, University of Colorado Boulder
Duncan Mackie, PhD
Director of Pharmacology & Experimental Therapeutics, MedPharm Holdings
This project constitutes an independent and comprehensive evaluation of cannabis product label claims and testing infrastructure in the State of Colorado. The primary aim is to determine the actual cannabinoid potency (via […]
Cannabinoid Conversion to CBN During Hemp Extraction and Post-Extraction Fluorination of CBD and CBN for Increased Bioavailability (2021)
Ken Olejar, PhD
Colorado State University Pueblo
Large numbers of therapies originate from compounds originating in plants. Cannabinoids produced by industrial hemp are a group of compounds that are emerging for potential medical use. One problem that exists with all-natural compounds is their bioavailability. Studies have shown that when many of these compounds are given at therapeutic […]