Examining the adaptive roles of plant defensive chemistry on pest resistance in Cannabis sativa (2022)

Punya Nachappa, PhD
Associate Professor, Entomology, Department of Agricultural Biology, Colorado State University

Understanding how plants respond to insect herbivores can provide new insights into plant-insect chemical communication and coevolution and facilitate new approaches to crop protection. Cannabis is known for the presence of cannabinoids, which include Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) and more than 100 related secondary metabolites. In addition to cannabinoids, C. sativa also possesses a range of defense mechanisms (namely terpenes and phenolic compounds) that are conserved across dicots and well described in other model plant species. To date, no study has analyzed the degree to which cannabinoids confer pest resistance relative to other defensive traits in C. sativa. Hence, the goal of our project is to understand how variation in secondary metabolites in C. sativa affects key hemp pests by using and developing novel genetic tools and technology. Outcomes of this research will not only advance basic research in the field of plant-insect coevolution but also has practical applications for breeding for pest resistance in hemp.

More FY23 Research

Edible Roulette or a Sure Bet? Evaluating Testing Standards and Consistency in Colorado’s Edible Products (2024)

Duncan Mackie, PhD,
Director of Pharmacology & Experimental Therapeutics, MedPharm Holdings

Cinnamon Bidwell, PhD,
Institute of Cognitive Science Faculty, Assistant Professor, University of Colorado Boulder

...

Cannabinoids and Traumatic Brain Injury: A Randomized, Placebo Controlled Trial (2022)

Kent Hutchison, PhD
Institute of Cognitive Science Affiliated Faculty & Professor, University of Colorado Boulder

Traumatic brain injury (TBI) represents a major public health burden due...

Potential Health Effects of Heavy Metals in Cannabis Flower, Concentrates, Vape Devices, and Vape Emissions (2022)

Mike Van Dyke, PhD
Associate Professor, Center for Health, Work, and Environment, Colorado School of Public Health, University of Colorado Anschutz Medical Campus

Inhalation exposure to...

Examining the adaptive roles of plant defensive chemistry on pest resistance in Cannabis sativa (2022)

Punya Nachappa, PhD
Associate Professor, Entomology, Department of Agricultural Biology, Colorado State University

Understanding how plants respond to insect herbivores can provide new insights into plant-insect...

Isolation and Pharmacological Evaluation of Phytocannabinoids for Alzheimer’s Disease (2022)

Duncan Mackie, PhD,
Director of Pharmacology & Experimental Therapeutics, MedPharm Holdings

Cinnamon Bidwell, PhD,
Institute of Cognitive Science Faculty, Assistant Professor, University of Colorado Boulder

...

Preventative and treatment effects of broad-spectrum cannabidiol (CBD) in a rat model of comorbid autism and epilepsy: A mechanistic study (2022)

Christopher Lowry, PhD
Associate Professor, Integrative Physiology, University of Colorado Boulder

Over 50% of children with autism spectrum disorder (ASD) show sub-clinical epileptic spikes by adolescence...