Endocannabinoids in Children with Autism Spectrum Disorder and Changes with Cannabidiol (CBD) treatment (2024)

Nicole Tartaglia, MD
Professor, Pediatrics-Developmental Pediatrics University of Colorado Anschutz Medical Campus

Children with autism often struggle with behavioral challenges including irritability, anxiety, attention deficits, aggressive behaviors or self-injurious behaviors. Endocannabinoids are naturally occurring substances in the human body that bind to cannabinoid receptors and have actions across the body including significant effects on […]

Investigation of polycyclic aromatic hydrocarbons resulting from vaped or dabbed cannabis/cannabis-derived products with known adverse health effects (2024)

Alison Bauer, PhD
Associate Professor, Department of Environmental & Occupational Health, University of Colorado Anschutz Medical Campus

According to the 2021 Health Kids Survey (CDPHE), among kids who use cannabis in Colorado, ~16% vape and ~22% dab cannabis. Cannabis vaping and electronic dabbing could lead to emissions of toxicants that are currently not tested, that are […]

Identifying the neuronal cell-types responsible for the rewarding and aversive properties of THC (2024)

David Root, PhD
Assistant Professor, Department of Psychology and Neuroscience, University of Colorado Boulder

Marijuana is among the most widely used psychoactive substances across the world. The active ingredient in marijuana, Δ9-tetrahydrocannabinol (THC), has rewarding qualities and some individuals will become addicted to using it. THC has aversive properties as well at higher doses. On the […]

Cannabinoids and Traumatic Brain Injury: A Randomized, Placebo Controlled Trial (2023)

Kent Hutchison, PhD
Institute of Cognitive Science Affiliated Faculty & Professor, University of Colorado Boulder

Traumatic brain injury (TBI) represents a major public health burden due to chronic neuropsychiatric sequelae (emotional, physical and cognitive) that negatively affect vocational activities, interpersonal relationships and independent living. Responses of these chronic symptoms to any particular treatment are both variable […]

Potential Health Effects of Heavy Metals in Cannabis Flower, Concentrates, Vape Devices, and Vape Emissions (2023)

Mike Van Dyke, PhD
Associate Professor, Center for Health, Work, and Environment, Colorado School of Public Health, University of Colorado Anschutz Medical Campus

Inhalation exposure to heavy metals such as lead, cadmium, arsenic, nickel, mercury, and manganese can increase the risk for cancer as well as neurological, renal, cardiovascular, and hepatic outcomes. Smoking or vaping cannabis […]

Isolation and Pharmacological Evaluation of Phytocannabinoids for Alzheimer’s Disease (2023)

Duncan Mackie, PhD,
Director of Pharmacology & Experimental Therapeutics, MedPharm Holdings

Cinnamon Bidwell, PhD,
Institute of Cognitive Science Faculty, Assistant Professor, University of Colorado Boulder

Our research group has a longstanding interest in the activity of cannabinoids for the treatment of inflammatory neurological diseases such as Alzheimer’s disease. The purpose of this proposal is to further develop […]

Preventative and treatment effects of broad-spectrum cannabidiol (CBD) in a rat model of comorbid autism and epilepsy: A mechanistic study (2023)

Christopher Lowry, PhD
Associate Professor, Integrative Physiology, University of Colorado Boulder

Over 50% of children with autism spectrum disorder (ASD) show sub-clinical epileptic spikes by adolescence and 5-40% develop chronic epilepsy. Similarly, approximately 30% of children with epilepsy are also diagnosed with ASD. As a likely etiology, the role of inflammation in epilepsy is under intense […]

Dissecting the Genetic Basis of Sex and Dioecy in Cannabis Sativa (2022)

Nolan Kane, PhD

Associate Professor, Ecology and Evolutionary Biology, University of Colorado Boulder

As hemp continues to become an ever more economically valuable/important crop, it becomes increasingly necessary to understand the mechanism of sex determination. Understanding these processes will help to develop new approaches, tools, and pipelines, which will propel Cannabis into the modern era as […]

Quantification of Endo- and Phytocannabinoids with Comparison to Pain Medication Requirements and Surgical Outcomes for Patients Undergoing Abdominal Surgery for Cancer (2022)

Camille Stewart, MD
Assistant Professor of Surgery, Division of Surgical Oncology, University of Colorado Anschutz Medical Campus

The use of cannabis is expanding in the United States. There is, however, a critical lacking in our understanding of how cannabis and its associated chemical compounds, called cannabinoids, affect patients after surgery. Patients undergoing abdominal surgery have substantial […]