Examination of the bi-directional interactions between phytocannabinoids and a human-associated gut microbiota (2024)

Jessica Prenni, PhD, and Tiffany Weir, PhD
Associate Professor, Department of Horticulture and Landscape Architecture (JP), and Professor, Food Science and Human Nutrition (TW), Colorado State University

In recent decades, the gut microbiome has emerged as a critical regulator of inflammation and immunity in humans and has been associated with the development of numerous chronic […]

Developing predictive models to distinguish alcohol use, cannabis use and co-use: an exploration of electroenceph-alography (EEG) metrics and traditional intoxication measures (2024)

Hollis Karoly, PhD and Patti Davies, PhD
Assistant Professor, Department of Psychology (HK), and Professor, Department of Occupational Therapy (PD), Colorado State University

Alcohol and cannabis are commonly used at the same time and are both known to impair cognitive and psychomotor functions relevant for driving. Following legalization of recreational cannabis in Colorado, DUIs involving cannabis […]

Increasing the Analytical Testing Capability of Cannabinoids and Concomitant Phytomolecules in Cannabis-derived Plant Matrices (2024)

William Baurerle, PhD
Professor, Department of Horticulture and Landscape Architecture, Colorado State University

Water for irrigation and essential elements for plant nutrition, two critical inputs for Cannabis production, are finite resources. We aim to quantify Cannabis crop essential element and water use requirements in intensive horticulture production systems. Quantitative data of this nature provides mineral nutrient […]

Examining the adaptive roles of plant defensive chemistry on pest resistance in Cannabis sativa (2023)

Punya Nachappa, PhD
Associate Professor, Entomology, Department of Agricultural Biology, Colorado State University

Understanding how plants respond to insect herbivores can provide new insights into plant-insect chemical communication and coevolution and facilitate new approaches to crop protection. Cannabis is known for the presence of cannabinoids, which include Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) and more than 100 […]

Investigating the Effect of Cannabidiol and Cannabidiol-trazodone Combination Treatment on Naturally Occurring Canine Cognitive Dysfunction Syndrome as a Surrogate for Alzheimer’s Disease (2022)

Stephanie McGrath, PhD
Associate Professor, Neurology, Colorado State University

The World Health Organization predicts that Alzheimer’s disease (AD) and other dementias will be the second leading cause of death in the United States within the next decade. Unfortunately, multimodal treatment efforts, with drugs, vaccines, and stem cell therapies, have yet to be successful. Neurodegenerative disorders are […]

Exploring Intoxication During Acute Alcohol and Cannabis Co-Administration: A Focus on Cannabinoid Content and Order Effects (2022)

Hollis Karoly, PhD
Assistant Professor, Department of Psychology, Colorado State University

Cannabis is the most commonly used drug among people who drink alcohol, yet evidence on the effects of using these substances together is quite limited. Two important factors that might impact the relationship between cannabis and alcohol use are the specific type of cannabis used […]

Cannabinoid Conversion to CBN During Hemp Extraction and Post-Extraction Fluorination of CBD and CBN for Increased Bioavailability (2022)

Ken Olejar, PhD
Colorado State University Pueblo

Large numbers of therapies originate from compounds originating in plants. Cannabinoids produced by industrial hemp are a group of compounds that are emerging for potential medical use. One problem that exists with all-natural compounds is their bioavailability. Studies have shown that when many of these compounds are given at therapeutic […]